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Five Distinct Mutation Signatures Explain Why Some Tumors Evade Immunotherapy

Researchers at the Hungarian Centre of Excellence for Molecular Medicine (HCEMM) have identified five dominant patterns of protein-altering mutations in cancer that help determine how tumors interact with the immune system. The research, published in Molecular Systems Biology, showed that rather than just simple tumor mutation burden, five distinct patterns of protein-altering mutations, called amino acid substitution signatures help determine ...

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